Dr. Pankaj Bhalla, Ph.D., Ph.D.

Migraine is a neurovascular disorder of which the pathophysiology is not completely understood.  In line with the proposed neurovascular hypothesis, several experimental animal models have been developed that may explain the efficacy of acutely acting anti-migraine drugs.  The predictive value of these models for migraine therapy is based on: (i) the involvement of the trigeminovascular system, i.e. inhibition of plasma protein extravasation; (ii) central trigeminal inhibition and, thereby, reducing the release of neuropeptides (e.g. calcitonin gene related peptide); (iii) vasoconstriction of cranial extracerebral (e.g. within carotid) vascular beds or isolated blood vessels; or (iv) by a combination of these mechanisms.  It is important to note, however, that irrespective of the mechanisms involved, selective vasoconstriction within the carotid circulation is an important property of acutely acting anti-migraine drugs.  Constriction of porcine carotid arteriovenous anastomoses is a well‑established model for evaluating anti-migraine activity of 5‑HT‑based compounds.  To complement this in vivo experimental model, we developed strategies for rapidly screening a number of potential anti-migraine drugs.  For this purpose, we have cloned, sequenced and pharmacologically characterized porcine specific 5‑HT_1B, 5‑HT_1D, 5‑ht_1F and 5‑HT₇ receptors. These receptors could be of importance in unraveling mechanisms underlying the pathogeneses of migraine and may help in developing effective therapeutic strategies.

Notes From Editor:
	I extend my sincere gratitude to receive this abstract from 
	Dr. P. Bhalla.	The abstract presented above has originated 
	from the bench of this experienced researcher. This is an opening 
	abstract on the subject "Migraine". I added Dr. Bhalla's email
	to answer some 	specific questions or take a comment. He has 
	taken a step to share his views with us, and we admire his gesture. 
	
	To address the interests of general audience, I would try to
	establish some relevant links that will bridge his findings 
	with the current concepts on this juncture. Please consider, 
	viewing the references 	(**), I felt very informative. 
	
	If readers are interested, may visit Migraine Action 
	Association (UK), for FAQ. Behind 	the myths of triggering 
	migraines and pathways, the receptors are expected to play a 
	major role, and the major challenges are to identify, 
	characterize and modularize these 	receptors. This abstract
	addresses the events that orchestrate migraine and possible
	strategy to control migraines. 
	
	The receptors like 5-HT1B inhibit the release of a range of 
	neurotransmitters, including 	serotonin, GABA, acetylcholine,
	and glutamate. 
	

	Manas K Mukherjee, Ph.D. 
	( Medical Microbiology)

** Reference on-line 

	
http://www.neurologychannel.com/migraine/
	
http://www.bio-balance.com/BB5.html. and its links
	

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